Computational Genomics in the Era of Precision Medicine: Applications to Variant Analysis and Gene Therapy.

Rapid methodological advances in statistical and computational genomics have enabled researchers to better identify and interpret both rare and common variants responsible for complex human diseases. Additionally, we discuss the strategy, challenge, and promise of gene therapy.

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• 1 As we continue to see an expansion of these advances in the field, it is now imperative for researchers to understand the resources and methodologies available for various data types and study designs.
• 2 In this review, we provide an overview of recent methods for identifying rare and common variants and understanding their roles in disease etiology.
• 3 Additionally, we discuss the strategy, challenge, and promise of gene therapy.

Understanding this could lead to better treatments, improved diagnostics, or a deeper grasp of how the human body works — benefiting patient care globally.

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