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Acquired Resistance to KRAS G12C Inhibition in Cancer

📅 Published: June 23, 2021 👤 Mark M. Awad, Shengwu Liu, Igor I. Rybkin et al. 📖 New England Journal of Medicine 📊 1,156 citations
AI-Generated Summary

The mechanisms of acquired resistance to these therapies are currently unknown. CONCLUSIONS: inhibitors, and new therapeutic strategies are required to delay and overcome this drug resistance in patients with cancer.

⚡ This is an original paraphrased summary — not copied from the abstract. Full paper available at the source link below.

Key Findings
  • 1 CONCLUSIONS: inhibitors, and new therapeutic strategies are required to delay and overcome this drug resistance in patients with cancer.
  • 2 (Funded by Mirati Therapeutics and others; ClinicalTrials.gov number, NCT03785249.).
Why It Matters

Understanding this could lead to better treatments, improved diagnostics, or a deeper grasp of how the human body works — benefiting patient care globally.

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